Nature of Science
The symptoms of dyspepsia include the overproduction of stomach acid. There are several different ways in which this can be treated. These includes the prescription of antacids to neutralize the acid, the use of H2-receptor antagonists and the use of proton pump inhibitors which work by preventing the production of stomach acid. The effectiveness of these different treatments can be assessed through collecting data by sampling and trialling.
The need for pH regulation of the stomach can be affected by the diet, lifestyle and genetics etc. of different cultures.
After studying this topic students should be able to:
- Antacids reduce excess stomach acid. (Article here on how antacids work)
- The active form(s) of a drug after it has been processed by the body are called active metabolites.
Apply their knowledge to:
- Explain how excess acidity in the stomach can be reduced by the use of different bases. (Article here on how antacids work)
- Construct and balance equations for neutralization reactions and apply theses equations using their stoichiometry. (For example : cheesy video here)
- Solve buffer problems using the Henderson–Hasselbalch equation. (What is a buffer and how to write K expressions video Here)
- Explain how compounds, such as ranitidine (Zantac), can be used to inhibit stomach acid production. (VIDEO Here on How ranitidine works)
- Explain how compounds, such as omeprazole (Prilosec) and esomeprazole (Nexium), are used to suppress acid secretion in the stomach. (Video here on proton pump inhibitors such as omeprazole)
H2 receptor antagonist
proton pump inhibitor